Professor Chow said there were still important research questions. “For people who may be having side effects from their current treatments, we would like to know whether a switch to an utra-low-dose combination can improve things.”
“Also, the WHO Hypertension Guidelines released this week, just like other recent hypertension guidelines in Europe, US and elsewhere, recommend most patients start on two blood pressure drugs rather than one. We need to know how that would compare to a quadpill strategy.”
There is also a major research translation challenge ahead: “These kinds of strategies will only make a major impact on global health if they are available and affordable for patients most in need,” said Professor Chow.
“When we find treatments that are this effective, simple and safe we must do our best to get them to those who can benefit most.”
Professor Chow said a simple and effective combination quadpill strategy had potential to impact people’s lives worldwide. “High blood pressure is the leading cause of preventable deaths globally – we hope our world-leading findings will be translated swiftly into a product available for the general public,” she concluded.
Reference: Chow CK, Atkins ER, Hillis GS, et al. Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial. The Lancet. 2021. doi: 10.1016/S0140-6736(21)01922-X
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